Hemoglobinopathies by HPLC: A 3 Year Study of 106,277 Cases

Introduction: Hemoglobinopathies and thalassemias are the most common single gene disorders in world. World Health Organization figures estimate that 5% of world populations carriers a potentially pathological hemoglobin (Hb) gene. The general incidence thalassemia trait sickle cell anaemia India varies between 3-17% 1-44% respectively3 but because consanguinity, caste area endogamy, some communities show very high incidence, making disease major public health problem our country. Cation exchange high-performance liquid chromatography (CE-HPLC) is one best methods for screening, detection, identification various hemoglobinopathies.
 Material &Method: A retrospective study was carried out from period 2017 to 2019 with 106277 cases evaluated an aim identify hemoglobinopathies seen Indian population by chromatography. Cases outside geographical location were excluded study
 Result: total 18,936(17.82%) abnormal haemoglobin variants reported 35 difference across India. Northeast maximum (50.16%). Beta Thalassemia Trait variant found.Such emphasises premarital prenatal screening prevention dangerous effects population.
 Conclusion: CE-HPLC should be used early detection proper management these haemoglobinopathies. hemoglobinopathy observed followed Sickle then disease. It also had hemoglobinopathies.